**That's it!** You now have approved and investigational drugs for the disease.

---

## Quick Recipes

### Find Drugs for a Disease

Returns: Approved + investigational drugs with max phase reached

### Find Disease Targets

Returns: Top disease targets ranked by evidence strength (0-1 score)

### Search Literature

Returns: PubMed articles on myasthenia gravis immunotherapy

### Find Active Clinical Trials

Returns: Actively recruiting trials for the disease

### Check Drug Safety

Returns: FDA adverse event reports—check for serious outcomes, death, hospitalization

---

## What You Get

**14+ Integrated Databases**

| Database | What's Inside | Use For |
|----------|---------------|---------|
| **ChEMBL** | 2M drugs, bioactivity data | Finding approved/investigational drugs |
| **OpenTargets** | Disease-target links + evidence | Identifying therapeutic targets |
| **PubMed** | 35M+ articles + preprints | Literature review & validation |
| **ClinicalTrials.gov** | 400K+ active trials | Finding ongoing studies |
| **OpenFDA** | Adverse events, drug labels | Safety assessment |
| **OMIM** | Genetic diseases, genes → phenotypes | Understanding disease genetics |
| **Reactome** | Pathways, protein interactions | Mechanism understanding |
| **UniProt** | Protein sequences, annotations | Protein properties |
| **KEGG** | Metabolic & disease pathways | Systems-level view |
| **GWAS Catalog** | Genetic associations | Variant discovery |
| **Pathway Commons** | Integrated pathway data | Network analysis |
| **MyGene.info** | Gene annotations | ID mapping |
| **MyVariant.info** | Variant effects | Variant interpretation |
| + more | | |

---

## Use Cases

### 🧬 Drug Repurposing
Find non-standard-care drugs for rare/complex diseases:
1. Find disease targets (OpenTargets)
2. Search for drugs targeting those genes (ChEMBL)
3. Check ongoing trials (ClinicalTrials)
4. Verify safety (OpenFDA, PubMed)

### 🔬 Target Discovery
Identify novel therapeutic targets:
1. Find disease associations (OpenTargets, GWAS)
2. Get pathway context (Reactome, KEGG)
3. Review literature (PubMed)
4. Check protein properties (UniProt)

### 📋 Clinical Evidence Review
Compile evidence for a hypothesis:
1. Search trials (ClinicalTrials.gov)
2. Find literature (PubMed)
3. Check FDA data (OpenFDA)

### 📊 Literature Mining
Systematically search biomedical research:
1. PubMed: 35M+ articles searchable by gene, disease, drug, chemical
2. Preprints: bioRxiv, medRxiv
3. Filter by keywords, date, study type

---

## API Endpoint

**Production (No setup needed):**

All 14+ databases unified into one endpoint.

**Running Locally:**

---

## Complete References

See detailed guides for each database:

- **[PubMed Guide](./references/pubmed.md)** — Literature search (genes, diseases, keywords)
- **[ClinicalTrials Guide](./references/clinical-trials.md)** — Find active trials
- **[ChEMBL Guide](./references/chembl.md)** — Drug-target data & bioactivity
- **[OpenTargets Guide](./references/opentargets.md)** — Disease-target associations
- **[OpenFDA Guide](./references/openfda.md)** — Drug safety & adverse events
- **[OMIM Guide](./references/omim.md)** — Genetic diseases (requires API key)
- **[Other APIs](./references/other-apis.md)** — Reactome, UniProt, KEGG, GWAS, etc.

---

## Workflow Example

**Complete Drug Repurposing Pipeline:**

See [drug-repurposing-workflow.md](./scripts/drug-repurposing-workflow.md) for step-by-step example with all 8 steps + curl commands.

---

## API Keys

Most APIs are **free, no key required**. Optional keys for higher rate limits:

| Database | Key? | Why | Get Key |
|----------|------|-----|---------|
| ChEMBL | No | Public data | (not needed) |
| OpenTargets | No | Public data | (not needed) |
| PubMed | No | Public data | (not needed) |
| ClinicalTrials | No | Public data | (not needed) |
| **OMIM** | **Yes** | Proprietary data | https://omim.org/api |
| OpenFDA | Optional | Higher rate limits | https://open.fda.gov |
| NCI Clinical Trials | Optional | Higher rate limits | https://clinicaltrialsapi.cancer.gov |

---

## Rate Limits & Caching

- **No authentication** for production endpoint (public)
- **Rate limits**: Generous (~1000+ requests/day per database)
- **Caching**: Automatic 30-day HTTP caching (RFC 9111)
- **Cost**: $0 (all databases public or researcher-accessible)

---

## Common Patterns

### Batch Query Loop

### ID Conversion

Need to convert IDs between databases?

# Find drugs for myasthenia gravis
curl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \
  -H "Content-Type: application/json" -H "Accept: application/json" \
  -d '{"jsonrpc":"2.0","method":"tools/call","params":{"name":"chembl_find_drugs_by_indication","arguments":{"indication":"myasthenia gravis","max_results":10}},"id":1}'